Thursday, May.2, 2024
miRNA:

hsa-miR-21
Disease:

breast cancer

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc
Expression pattern of miRNA:

up-regulated

Validated targets of miRNA from the reference:

PDCD4

Validated targets of miRNA from TarBase:

PTEN,TPM1 : More...
Predicted targets: MIRANDA, TARGETSCAN, PICTAR-VERT

 

Description:

Inhibition of mir-21 in MCF-7 breast cancer cells causes reduced cell growth.the tumor suppressor protein Programmed Cell Death 4 (PDCD4) is regulated by miR-21.

 

 

Reference:

Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells. | PMID:17991735
Frankel LB, Christoffersen NR, Jacobsen A, Lindow M, Krogh A, Lund AH.
J Biol Chem. 2008 Jan 11;283(2):1026-33. Epub 2007 Nov 8.

 
 
 
 
　 miRBase
　 Tarbase
　 miRGen
　 miRGator
　 CCBB
　 MicroRNA.org
　 miRRim
  miRNAMap 2.0
 
 
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