hsa-miR-21

breast cancer

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

up-regulated

Validated targets of miRNA from the reference:

PDCD4

Validated targets of miRNA from TarBase:

PTEN,TPM1 : More...

Description:

The translation of the tumor suppressor gene PDCD4 is negatively regulated by the miRNA miR-21 in HEK-293T, MCF-7 and JB6 cell lines, and provides evidence that the mir-21 gene functions as an oncogene to promote cell transformation.Reduced PDCD4 expression has been reported in at least six human tumor types or cancer cell lines (lung, brain, renal, breast, colon and pancreas),indicating that mir-21/PDCD4 is likely to be a clinically significant oncogene:tumor suppressor pair in the induction and progression of human carcinomas.

Reference:

MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene. | PMID:18372920
Lu Z, Liu M, Stribinskis V, Klinge CM, Ramos KS, Colburn NH, Li Y.
Oncogene. 2008 Jul 17;27(31):4373-9. Epub 2008 Mar 31.