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Friday, May.3, 2024
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| miRNA: |
hsa-miR-21 |
| Disease: |
cardiac hypertrophy |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
PTEN,TPM1 : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: 2'OMe-miR-21 decreased miR-21 levels and inhibited myocyte hypertrophy stimulated by either Ang II or PE as shown by the decreased cell size and leucine incorporation. In contrast, control oligos (2'OMe-EGFP) had no effect on miR-21 expression and cell hypertrophy. |
Reference:
MicroRNAs are aberrantly expressed in hypertrophic heart: do they play a role in cardiac hypertrophy? | PMID:17525252
Cheng Y, Ji R, Yue J, Yang J, Liu X, Chen H, Dean DB, Zhang C.
Am J Pathol. 2007 Jun;170(6):1831-40. |
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