hsa-miR-221

prostate cancer

Relationship type:

Unspecified

Detection method for miRNA expression:

northern blot, qRT-PCR etc

down-regulated

Validated targets of miRNA from the reference:

unknown

Validated targets of miRNA from TarBase:

KIT : More...

Description:

we found aberrant expression of several miRs, including the down-regulation of miR-221, in prostate carcinoma metastasis. Down-regulation of miR-221 was negatively correlated with the expression of the proto-oncogen c-kit in primary carcinoma. In a large study cohort, the prostate-specific oncomir miR-221 was progressively down-regulated in aggressive forms of prostate carcinoma. Down-regulation of miR-221 was associated with clinicopathological parameters, including the Gleason score and the clinical recurrence during follow up. Kaplan Meier estimates and Cox proportional hazard models showed that miR-221 down-regulation was linked to tumor progression and recurrence in a high risk prostate cancer cohort. Our results showed that progressive miR-221 down-regulation hallmarks metastasis and presents a novel prognostic marker in high risk prostate carcinoma.

Reference:

Expression of microRNA-221 is progressively reduced in aggressive prostate cancer and metastasis and predicts clinical recurrence. | PMID:19585579
Spahn M, Kneitz S, Scholz CJ, Nico S, Rüdiger T, Ströbel P, Riedmiller H, Kneitz B.
Int J Cancer. 2009 Jul 7.