Friday, Mar.29, 2024
miRNA:

hsa-miR-21

Disease:

cholangiocarcinoma

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

Expression pattern of miRNA:

up-regulated

Validated targets of miRNA from the reference:

PTEN

Validated targets of miRNA from TarBase:

PTEN,TPM1 : More...

Predicted targets: MIRANDA, TARGETSCAN, PICTAR-VERT

 

Description:

miR-21 directly alters PTEN expression and modulates gemcitabine-induced apoptosis by activating PI 3 kinase-signaling pathways.

 

 

Reference:

Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines. | PMID:16762633
Meng F, Henson R, Lang M, Wehbe H, Maheshwari S, Mendell JT, Jiang J, Schmittgen TD, Patel T.
Gastroenterology. 2006 Jun;130(7):2113-29.

 

 
 
 
  miRBase
  Tarbase
  miRGen
  miRGator
  CCBB
  MicroRNA.org
  miRRim
  miRNAMap 2.0
 
 
Please don't hesitate to address comments/questions/suggestions regarding this webpage to: ydwang@hit.edu.cn or yunliu@iu.edu