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Friday, Mar.29, 2024
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miRNA: |
hsa-miR-21 |
Disease: |
cholangiocarcinoma |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
PTEN |
Validated targets of miRNA from TarBase: |
PTEN,TPM1 : More... |
Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: miR-21 directly alters PTEN expression and modulates gemcitabine-induced apoptosis by activating PI 3 kinase-signaling pathways.
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Reference:
Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines. | PMID:16762633
Meng F, Henson R, Lang M, Wehbe H, Maheshwari S, Mendell JT, Jiang J, Schmittgen TD, Patel T.
Gastroenterology. 2006 Jun;130(7):2113-29. |
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