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Thursday, Apr.25, 2024
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| miRNA: |
hsa-miR-21 |
| Disease: |
glioblastoma |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
PTEN,TPM1 : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Knockdown of miR-21 in cultured glioblastoma cells triggers activation of caspases and leads to increased apoptotic cell death. |
Reference:
MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. | PMID:16024602
Chan JA, Krichevsky AM, Kosik KS.
Cancer Res. 2005 Jul 15;65(14):6029-33. |
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