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Thursday, Apr.25, 2024
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| miRNA: |
hsa-miR-21 |
| Disease: |
hepatocellular carcinoma (HCC) |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
PTEN |
Validated targets of miRNA from TarBase: |
PTEN,TPM1 : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Aberrant expression of miR-21 can contribute to HCC growth and spread by modulating PTEN expression and PTEN-dependent pathways involved in mediating phenotypic characteristics of cancer cells such as cell growth, migration, and invasion. |
Reference:
MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. | PMID:17681183
Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T.
Gastroenterology. 2007 Aug;133(2):647-58. Epub 2007 May 21. |
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