hsa-miR-135a

Hodgkin's lymphoma

Relationship type:

Causal

Detection method for miRNA expression:

northern blot, qRT-PCR etc

down-regulated

Validated targets of miRNA from the reference:

JAK2

Validated targets of miRNA from TarBase:

unknown : More...

Description:

Patients with low miR-135a expression had a higher probability of relapse (p=0.04) and a shorter disease-free survival (p=0.02). Functional analysis of cHL cell lines showed that mature miR-135a levels increased following pre-miR-135a transfection, causing apoptosis and decreased cell growth. Target analysis showed a direct regulation by miR-135a of JAK2, a cytoplasmic tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. miR-135a-mediated JAK2 downregulation led to decreased mRNA and protein levels of the antiapoptotic gene Bcl-xL, suggesting a role for Bcl-xL in miR-135a/JAK2-mediated apoptosis. Our findings confirm the critical role of miR-135a in the survival of cHL cells and in the prognosis of cHL patients, indicating that novel treatment approaches targeting miR-135a may potentially benefit these patients.

Reference:

Regulation of JAK2 by miR-135a: prognostic impact in classical Hodgkin lymphoma. | PMID:19666866
Navarro A, Diaz T, Martinez A, Gaya A, Pons A, Gel B, Codony C, Ferrer G, Martinez C, Montserrat E, Monzo M.
Blood. 2009 Aug 7.