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Saturday, May.4, 2024
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miRNA: |
hsa-miR-21 |
Disease: |
pancreatic cancer |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
PDCD4 |
Validated targets of miRNA from TarBase: |
PTEN,TPM1 : More... |
Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: The overexpression of miR-21 is strongly associated with both a high Ki67 proliferation index and presence of liver metastasis. |
Reference:
MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior. | PMID:16966691
Roldo C, Missiaglia E, Hagan JP, Falconi M, Capelli P, Bersani S, Calin GA, Volinia S, Liu CG, Scarpa A, Croce CM.
J Clin Oncol. 2006 Oct 10;24(29):4677-84. Epub 2006 Sep 11. |
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