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Saturday, May.4, 2024
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| miRNA: |
hsa-miR-21 |
| Disease: |
vascular disease |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
PTEN, BCL2 |
Validated targets of miRNA from TarBase: |
PTEN,TPM1 : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Aberrant Expression of miRNA in Injured Arteries Is Confirmed by qRT-PCR or Northern Blot Analysis.Downregulation of overexpressed miR-21 decreases neointima formation in rat carotid artery after angioplasty.Inhibition of miR-21 decreases proliferation of cultured VSMCs.Inhibition of miR-21 increases apoptosis of cultured VSMCs. |
Reference:
MicroRNA expression signature and antisense-mediated depletion reveal an essential role of MicroRNA in vascular neointimal lesion formation. | PMID:17478730
Ji R, Cheng Y, Yue J, Yang J, Liu X, Chen H, Dean DB, Zhang C.
Circ Res. 2007 Jun 8;100(11):1579-88. Epub 2007 May 3. |
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