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Saturday, Apr.20, 2024
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| miRNA: |
hsa-miR-221 |
| Disease: |
acute promyelocytic leukemia (APL) |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
CDKN1B |
Validated targets of miRNA from TarBase: |
KIT : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Our analysis of data published by Lu etc. (1), showed that expression of miR-128b and miR-221 is downregulated in MLL rearranged ALL relative to other types of ALL. Re-expression of these miRNAs cooperatively sensitizes two cultured lines of MLL-AF4 ALL cells to glucocorticoids. Target genes downregulated by miR-128b include MLL, AF4, and both MLL-AF4 and AF4-MLL fusion genes; miR-221 downregulates CDKN1B. These results demonstrate that downregulation of miR-128b and miR-221 is implicated in glucocorticoid resistance, that restoration of their levels is a potentially promising therapeutic in MLL-AF4 ALL. |
Reference:
miR-128b is a potent glucocorticoid sensitizer in MLL-AF4 acute lymphocytic leukemia cells and exerts cooperative effects with miR-221 | PMID:19749093
Kotani A, Ha D, Hsieh J, Rao PK, Schotte D, den Boer ML, Armstrong SA, Lodish HF.
Blood. 2009 Sep 11. [Epub ahead of print] |
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