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Friday, Mar.29, 2024
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miRNA: |
hsa-miR-140 |
Disease: |
Hodgkin's lymphoma |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
microarray |
Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
HDAC4 : More... |
Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: We determined the expression of 360 miRNAs in microdissected HRS cells from nine cHL patients. These miRNA profiles were compared to those from four cHL cell lines and CD77(+) B-cells, yielding a distinct cHL signature of 12 over- and three underexpressed miRNAs. Our data suggest that miRNAs are implicated in the pathogenesis of Hodgkin lymphoma and prompt further investigations concerning their role in cHL.
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Reference:
Comparison of miRNA profiles of microdissected Hodgkin/Reed-Sternberg cells and Hodgkin cell lines versus CD77 B-cells reveals a distinct subset of differentially expressed miRNAs | PMID:19775296
Van Vlierberghe P, De Weer A, Mestdagh P, Feys T, De Preter K, De Paepe P, Lambein K, Vandesompele J, Van Roy N, Verhasselt B, Poppe B, Speleman F.
Br J Haematol. 2009 Sep 22. [Epub ahead of print] |
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