hsa-miR-345

Oral Carcinoma

Relationship type:

Unspecified

Detection method for miRNA expression:

northern blot, qRT-PCR etc

up-regulated

Validated targets of miRNA from the reference:

unknown

Validated targets of miRNA from TarBase:

unknown : More...

Description:

Deregulated miR expression has been implicated in cancer; however there are no studies implicating a miR signature associated with progression in Oral Squamous Cell Carcinoma (OSCC). Although OSCC may develop from oral leukoplakia, clinical and histological assessments have limited prognostic value in predicting which leukoplakic lesions will progress. Our aim was to quantify miR expression changes in leukoplakia and same-site OSCC, and to identify a miR signature associated with progression. We examined miR expression changes in 43 sequential progressive samples from 12 patients and 4 non-progressive leukoplakias from 4 different patients, using TaqMan Low Density Arrays (TLDA). The findings were validated using quantitative PCR in an independent cohort of 52 progressive dysplasias and OSCCs, and 5 non-progressive dysplasias. Global miR expression profiles distinguished progressive leukoplakia/OSCC from non-progressive leukoplakias/normal tissues. 109 miRs were highly expressed exclusively in progressive leukoplakia and invasive OSCC. miR-21, miR-181b and miR-345 expression was consistently increased and associated with increases in lesion severity during progression. Over-expression of miR-21, miR-181b and miR-345 may play an important role in malignant transformation. Our study provides the first evidence of a miR signature potentially useful for identifying leukoplakias at risk of malignant transformation.

Reference:

Identification of a microRNA signature associated with progression of leukoplakia to oral carcinoma. | PMID:19776030
Cervigne NK, Reis PP, Machado J, Sadikovic B, Bradley G, Galloni NN, Pintilie M, Jurisica I, Gilbert R, Gullane P, Irish J, Kamel-Reid S.
Hum Mol Genet. 2009 Sep 23. [Epub ahead of print]