hsa-miR-21

chronic lymphocytic leukemia (CLL)

Relationship type:

Unspecified

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

up-regulated

Validated targets of miRNA from the reference:

unknown

Validated targets of miRNA from TarBase:

PTEN,TPM1 : More...

Description:

miR-21 in CLL is on average 3.8-fold with a maximum of 10-fold compared to normal CD19 cells.

Reference:

Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia. | PMID:17327404
Fulci V, Chiaretti S, Goldoni M, Azzalin G, Carucci N, Tavolaro S, Castellano L, Magrelli A, Citarella F, Messina M, Maggio R, Peragine N, Santangelo S, Mauro FR, Landgraf P, Tuschl T, Weir DB, Chien M, Russo JJ, Ju J, Sheridan R, Sander C, Zavolan M, Guarini A, Foa R, Macino G.
Blood. 2007 Jun 1;109(11):4944-51. Epub 2007 Feb 27.