hsa-miR-21

colorectal cancer

Relationship type:

Unspecified

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

up-regulated

Validated targets of miRNA from the reference:

unknown

Validated targets of miRNA from TarBase:

PTEN,TPM1 : More...

Description:

The expression levels of miRNA is affected by wtp53. Down-regulation of wt-p53 via siRNA abolishes the effect of wt-p53 in regulating miRNAs in HCT-116 (wt-p53) cells.

Reference:

Differentially regulated micro-RNAs and actively translated messenger RNA transcripts by tumor suppressor p53 in colon cancer. | PMID:16609010
Xi Y, Shalgi R, Fodstad O, Pilpel Y, Ju J.
Clin Cancer Res. 2006 Apr 1;12(7 Pt 1):2014-24.