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Friday, May.3, 2024
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| miRNA: |
hsa-let-7a |
| Disease: |
lung cancer |
Relationship type: |
Causal |
Detection method for miRNA expression: |
northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
NIRF |
Validated targets of miRNA from TarBase: |
NF2 : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: In this study, we showed that let-7a, a member of let-7 family, negatively regulated the expression of NIRF through NIRF 3' UTR. We also showed that NIRF was required for the let-7a-mediated elevation of p21(WAF1). These findings suggest that growth-inhibitory effect of let-7a on the A549 cells in vitro and in vivo may be explained in part by le-7a-induced suppression of NIRF and elevation of p21(WAF1). This work reveals a novel regulatory mechanism for let-7a in the control of cellular proliferation and lung carcinogenesis. |
Reference:
Let-7a elevates p21(WAF1) levels by targeting of NIRF and suppresses the growth of A549 lung cancer cells | PMID:19818775
He X, Duan C, Chen J, Ou-Yang X, Zhang Z, Li C, Peng H.
FEBS Lett. 2009 Nov 3;583(21):3501-7. Epub 2009 Oct 8. |
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