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Wednesday, May.8, 2024
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| miRNA: |
hsa-miR--196a-2 |
| Disease: |
gastric cancer (stomach cancer) |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: In the present study, we found that a significantly increased risk of gastric cancer in subjects with the variant homozygote CC of miR-196a-2 compared with wild-type homozygote TT and heterozygote CT carriers (adjusted odds ratio (OR)=1.57, 95% confidence interval (CI =1.03-2.39, P=0.038). Stratified analyses indicated that the variant homozygote CC genotype had a strong association with lymph node metastasis of gastric cancer (adjusted OR=2.25, 95% CI=1.21-4.18, P=0.011). CONCLUSIONS: These findings suggest that the genetic variant within miR-196a-2 could play an important role in the development and progression of gastric cancer. We expect the findings may be helpful to better understand the mechanism of gastric carcinogenesis. |
Reference:
Association of MicroRNA-196a-2 Gene Polymorphism with Gastric Cancer Risk in a Chinese Population | PMID:19834808
Peng S, Kuang Z, Sheng C, Zhang Y, Xu H, Cheng Q.
Dig Dis Sci. 2009 Oct 16. [Epub ahead of print] |
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