hsa-miR-145

colorectal cancer

Relationship type:

Unspecified

Detection method for miRNA expression:

microarray

down-regulated

Validated targets of miRNA from the reference:

unknown

Validated targets of miRNA from TarBase:

FLJ21308 : More...

Description:

he expression analysis of clinical CRC samples identified 37 miRNAs that were differentially expressed between CRC and normal tissue. Furthermore, several of these miRNAs were associated with CRC tumor progression including loss of miR-133a and gain of miR-224. We identified 11 common miRNAs that were differentially expressed between normal colon and CRC in both the cell line models and clinical samples. In vitro functional studies indicated that miR-143 and miR-145 appear to function in opposing manners to either inhibit or augment cell proliferation in a metastatic CRC model. The pathways targeted by miR-143 and miR-145 showed no significant overlap. Furthermore, gene expression analysis of metastatic versus non-metastatic isogenic cell lines indicated that miR-145 targets involved in cell cycle and neuregulin pathways were significantly down-regulated in the metastatic context.

Reference:

Characterization of global microRNA expression reveals oncogenic potential of miR-145 in metastatic colorectal cancer | PMID:19843336
Arndt GM, Dossey L, Cullen LM, Lai A, Druker R, Eisbacher M, Zhang C, Tran N, Fan H, Retzlaff K, Bittner A, Raponi M.
BMC Cancer. 2009 Oct 20;9:374.