hsa-miR-99b

multiple myeloma (MM)

Relationship type:

Unspecified

Detection method for miRNA expression:

microarray

up-regulated

Validated targets of miRNA from the reference:

unknown

Validated targets of miRNA from TarBase:

unknown : More...

Description:

To characterize miRNA in the context of the major MM molecular types, we generated miRNA expression profiles of highly-purified malignant plasma cells from 40 primary tumors. Furthermore, transcriptional profiles, available for all patients, were used to investigate the occurrence of miRNA/predicted target mRNA pairs anti-correlations, and the miRNA and genome-wide DNA data were integrated in a subset of patients to evaluate the influence of allelic imbalances on miRNA expression. Differential miRNA expression patterns were identified which were mainly associated with the major IGH translocations: particularly, t(4;14) patients showed specific over-expression of let-7e, miR-125a-5p and miR-99b belonging to a cluster at 19q13.33. The occurrence of other lesions, i.e. 1q gain, 13q and 17p deletions, and hyperdiploidy, was slightly characterized by specific miRNA signatures. Furthermore, the occurrence of several allelic imbalances or loss-of-heterozygosity was found significantly associated with the altered expression of miRNAs located in the involved regions, such as let-7b at 22q13.31 or miR-140-3p at 16q22. Finally, the integrative analysis based on computational target prediction and miRNA/mRNA profiling defined a network of putative functional miRNA-target regulatory relations supported by expression data.

Reference:

Identification of microRNA expression patterns and definition of a microRNA/mRNA regulatory network in distinct molecular groups of multiple myeloma | PMID:19846888
Lionetti M, Biasiolo M, Agnelli L, Todoerti K, Mosca L, Fabris S, Sales G, Lambertenghi Deliliers G, Bicciato S, Lombardi L, Bortoluzzi S, Neri A.
Blood. 2009 Oct 21. [Epub ahead of print]