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Friday, Apr.26, 2024
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| miRNA: |
hsa-miR-222 |
| Disease: |
papillary thyroid carcinoma (PTC) |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
microarray |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
KIT : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Three sublines with progressive invasiveness, designated IHH-4M-1, IHH- 4M-2 and IHH-4M-3, were obtained through this in vitro selection process. The sublines manifested an increase in colony-forming ability on soft agar and metastatic potency in nude mice. Then metastasis-related miRNAs differentially expressed between them were analyzed utilizing the miRNA microarray technique. We found that 11 metastasis-related miRNAs were differentially expressed between the invasive subpopulations and their control subpopulations; these miRNAs may account for their significant difference in the invasion capabilities and favor lymphatic metastasis of PTC. |
Reference:
miRNA Expression in a Human Papillary Thyroid Carcinoma Cell Line Varies with Invasiveness | PMID:19851034
Gao Y, Wang C, Shan Z, Guan H, Mao J, Fan C, Wang H, Zhang H, Teng W.
Endocr J. 2009 Oct 23. [Epub ahead of print] |
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