hsa-miR-21

glioma

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

up-regulated

Validated targets of miRNA from the reference:

unknown

Validated targets of miRNA from TarBase:

PTEN,TPM1 : More...

Description:

Pretreatment of glioma cells with locked nucleic acid (LNA)-antimiR-21 molecules leads to synergistic antitumor efficacy both in vitro and in vivo.

Reference:

MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas. | PMID:17908999
Corsten MF, Miranda R, Kasmieh R, Krichevsky AM, Weissleder R, Shah K.
Cancer Res. 2007 Oct 1;67(19):8994-9000.