|
|
|
|
Friday, May.3, 2024
|
|
|
|
|
|
| miRNA: |
hsa-miR-21 |
| Disease: |
glioma |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
RECK, TIMP3 |
Validated targets of miRNA from TarBase: |
PTEN,TPM1 : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: We demonstrate that miR-21 regulates multiple genes associated with glioma cell apoptosis, migration, and invasiveness, including RECK and TIMP3, suppressors of malignancy and inhibitors of matrix metalloproteinases (MMPs). Our data suggest that miR-21 contributes to the glioma malignancy by down-regulation of MMP inhibitors that leads to activation of MMPs thus promoting invasiveness of cancer cells. Our results also indicate that inhibition of a single oncomir like miR-21 with specific antisense molecules can provide a novel therapeutic approach for "physiological" modulation of multiple proteins whose expression is de-regulated in cancer.
|
Reference:
MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. | PMID:18591254
Gabriely G, Wurdinger T, Kesari S, Esau CC, Burchard J, Linsley PS, Krichevsky AM.
Mol Cell Biol. 2008 Sep;28(17):5369-80. Epub 2008 Jun 30. |
|
|
|
|
|
|
