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Friday, May.3, 2024
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miRNA: |
hsa-miR-21 |
Disease: |
uterine leiomyoma (ULM) |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
PTEN,TPM1 : More... |
Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Real-time reverse transcriptase polymerase chain reaction (RT-PCR) validation of microarray. Realtime
semiquantitative RT-PCR of five different microRNA species (miR-21, miR-34a, miR-125b, miR-139, and miR-323) across ten subjects. miR-21, miR-34a, miR-125b, and miR-323 were overexpressed in leiomyoma in the ten pairs tested and miR-139 was underexpressed, consistent with the microarray results. |
Reference:
Differential expression of microRNA species in human uterine leiomyoma versus normal myometrium. | PMID:17765232
Marsh EE, Lin Z, Yin P, Milad M, Chakravarti D, Bulun SE.
Fertil Steril. 2008 Jun;89(6):1771-6. Epub 2007 Sep 4. |
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