hsa-miR-210

diffuse large B-cell lymphoma (DLBCL)

Relationship type:

Unspecified

Detection method for miRNA expression:

microarray

up-regulated

Validated targets of miRNA from the reference:

unknown

Validated targets of miRNA from TarBase:

unknown : More...

Description:

Four hsa-miR-As (miR-210, hsa-miR-155, hsa-miR-106a, hsa-miR-17-5p) were expressed at a significantly higher level in DLBCL than in normal tissue. In contrast, the remaining 11 miRNAs (hsa-miR-150, hsa-miR-145, hsa-miR-328, hsa-miR-139, hsa-miR-99a, hsa-miR-10a, hsa-miR-95, hsa-miR-149, hsa-miR-320, hsa-miR-151,let-7e) were expressed at a significantly lower level in DLBCL.A classification tree was computed using four miRNAs (miR-330, miR-17-5p, miR-106a and miR-210) to correctly identify 98% of all 111 cases that were analysed in this study.

Reference:

MicroRNA signatures characterize diffuse large B-cell lymphomas and follicular lymphomas. | PMID:18537969
Roehle A, Hoefig KP, Repsilber D, Thorns C, Ziepert M, Wesche KO, Thiere M, Loeffler M, Klapper W, Pfreundschuh M, Matolcsy A, Bernd HW, Reiniger L, Merz H, Feller AC.
Br J Haematol. 2008 Jun 3. [Epub ahead of print]