hsa-miR-212

alcoholic liver disease (ALD)

Relationship type:

Unspecified

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

up-regulated

Validated targets of miRNA from the reference:

ZO-1

Validated targets of miRNA from TarBase:

unknown : More...

Description:

EtOH induces miR-212 over-expression which causes gut leakiness by down-regulating ZO-1 translation.

Reference:

Effect of alcohol on miR-212 expression in intestinal epithelial cells and its potential role in alcoholic liver disease. | PMID:18162065
Tang Y, Banan A, Forsyth CB, Fields JZ, Lau CK, Zhang LJ, Keshavarzian A.
Alcohol Clin Exp Res. 2008 Feb;32(2):355-64. Epub 2007 Dec 21.