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Friday, May.10, 2024
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| miRNA: |
hsa-miR-218 |
| Disease: |
cervical cancer |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
LAMB3 |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: microRNA-218 (miR-218) was specifically underexpressed in HPV-positive cell lines, cervical lesions and cancer tissues containing HPV-16 DNA compared to both C-33A and the normal cervix.Expression of the E6 oncogene of high-risk HPV-16, but not that of low-risk HPV-6, reduced miR-218 expression, and conversely, RNA interference of E6/E7 oncogenes in an HPV-16-positive cell line increased miR-218 expression. We also demonstrate that the epithelial cell-specific marker LAMB3 is a target of miR-218. We also show that LAMB3 expression is increased in the presence of the HPV-16 E6 oncogene and this effect is mediated through miR-218. |
Reference:
Human papillomavirus type 16 reduces the expression of microRNA-218 in cervical carcinoma cells. | PMID:17998940
Martinez I, Gardiner AS, Board KF, Monzon FA, Edwards RP, Khan SA.
Oncogene. 2008 Apr 17;27(18):2575-82. Epub 2007 Nov 12. |
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