Thursday, Mar.28, 2024
miRNA:

hsa-miR-22

Disease:

acute lymphoblastic leukemia (ALL)

Relationship type:

Unspecified

Detection method for miRNA expression:

microarray

Expression pattern of miRNA:

down-regulated

Validated targets of miRNA from the reference:

unknown

Validated targets of miRNA from TarBase:

unknown : More...

Predicted targets: MIRANDA, TARGETSCAN, PICTAR-VERT

 

Description:

Six (i.e., miR-128a,miR-128b, miR-151*, miR-5, miR-130b, and miR-210) were expressed at a significantly higher level in ALL than in AML. In contrast, the remaining 21 (i.e., let-7b, miR-223, let-7e, miR-125a, miR-130a, miR-221, miR-222, miR-23a, miR-23b, miR-24, miR-27a, miR-27b, let-7a,let-7c, miR-199b, miR-26a, miR-335, miR-21,miR-22, miR-424, and miR-451) were expressed at a significantly higher level in AML compared with ALL.

 

 

Reference:

MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia. | PMID:18056805
Mi S, Lu J, Sun M, Li Z, Zhang H, Neilly MB, Wang Y, Qian Z, Jin J, Zhang Y, Bohlander SK, Le Beau MM, Larson RA, Golub TR, Rowley JD, Chen J.
Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19971-6. Epub 2007 Dec 4.

 

 
 
 
  miRBase
  Tarbase
  miRGen
  miRGator
  CCBB
  MicroRNA.org
  miRRim
  miRNAMap 2.0
 
 
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