hsa-miR-16

chronic lymphocytic leukemia (CLL)

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

down-regulated

Validated targets of miRNA from the reference:

BCL2

Validated targets of miRNA from TarBase:

BCL2,CGI-38 : More...

Description:

Levels of miR-16 was decreased in NZB lymphoid tissue. Exogenous miR-16 delivered to an NZB malignant B-1 cell line resulted in cellcycle alterations and increased apoptosis.

Reference:

Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice. | PMID:17351108
Raveche ES, Salerno E, Scaglione BJ, Manohar V, Abbasi F, Lin YC, Fredrickson T, Landgraf P, Ramachandra S, Huppi K, Toro JR, Zenger VE, Metcalf RA, Marti GE.
Blood. 2007 Jun 15;109(12):5079-86. Epub 2007 Mar 9.