Thursday, Mar.28, 2024
miRNA:

hsa-miR-16-1

Disease:

acute promyelocytic leukemia (APL)

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

Expression pattern of miRNA:

up-regulated

Validated targets of miRNA from the reference:

BCL2, RAS

Validated targets of miRNA from TarBase:

unknown : More...

Predicted targets: MIRANDA, TARGETSCAN, PICTAR-VERT

 

Description:

Upregulation of miR-15a,miR-15b, miR-16-1, let-7a-3, let-7c, let-7d, miR-223,miR-342 and miR-107, whereas miR-181b was downregulated in in acute promyelocytic leukemia patients and cell lines during all-trans-retinoic acid (ATRA) treatment.

 

 

Reference:

MicroRNA gene expression during retinoic acid-induced differentiation of human acute promyelocytic leukemia. | PMID:17260024
Garzon R, Pichiorri F, Palumbo T, Visentini M, Aqeilan R, Cimmino A, Wang H, Sun H, Volinia S, Alder H, Calin GA, Liu CG, Andreeff M, Croce CM.
Oncogene. 2007 Jun 14;26(28):4148-57. Epub 2007 Jan 29.

 

 
 
 
  miRBase
  Tarbase
  miRGen
  miRGator
  CCBB
  MicroRNA.org
  miRRim
  miRNAMap 2.0
 
 
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