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Tuesday, Apr.23, 2024
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| miRNA: |
hsa-miR-16-1 |
| Disease: |
mantle cell lymphoma (MCL) |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
normal |
Validated targets of miRNA from the reference: |
CCND1 |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Truncated CCND1 mRNA expression leads to increased total CCND1 mRNA, increased CCND1 protein expression, and increased S phase fraction in MCL cell lines. This truncation deletes miR-16-1 binding sites within the CCND1 mRNA 3'UTR and alters miRNA regulation of MCL. |
Reference:
Truncation in CCND1 mRNA alters miR-16-1 regulation in mantle cell lymphoma. | PMID:18483394
Chen RW, Bemis LT, Amato CM, Myint H, Tran H, Birks DK, Eckhardt SG, Robinson WA.
Blood. 2008 Aug 1;112(3):822-9. Epub 2008 May 15. |
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