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Saturday, May.18, 2024
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| miRNA: |
hsa-miR-1 |
| Disease: |
cardiac hypertrophy |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
RasGAP,Cdk9, fibronectin,Rheb |
Validated targets of miRNA from TarBase: |
GJA1,Hand2,HDAC4,TMSB4X : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: The muscle-specific miR-1 was singularly downregulated as early as day 1, persisting through day 7, after aortic constriction–induced hypertrophy in a mouse model. Overexpression experiments showed that miR-1 inhibited its in silico–predicted, growth-related targets, including Ras GTPase–activating protein (RasGAP), cyclin-dependent kinase 9 (Cdk9), fibronectin, and Ras homolog enriched in brain (Rheb), in addition to protein synthesis and cell size. |
Reference:
MicroRNAs play an essential role in the development of cardiac hypertrophy. | PMID:17234972
Sayed D, Hong C, Chen IY, Lypowy J, Abdellatif M.
Circ Res. 2007 Feb 16;100(3):416-24. Epub 2007 Jan 18. |
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