| miRNA: |
hsa-miR-17-3p |
| Disease: |
MYC-rearranged lymphoma |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
TβRII |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Myc can upregulate the miR-17 cluster by binding directly upstream of the miR-17 locus.Deregulation of the miR-17 polycistron can be assumed to contribute to aggressive cancer development by repressing tumor suppressor genes.TβRII is the direct downstream target of the miR-17 polycistron. |
Reference:
Synergistic action of the microRNA-17 polycistron and Myc in aggressive cancer development. | PMID:17608773
Tagawa H, Karube K, Tsuzuki S, Ohshima K, Seto M.
Cancer Sci. 2007 Sep;98(9):1482-90. Epub 2007 Jun 30. |
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