hsa-miR-429

cancer

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

down-regulated

Validated targets of miRNA from the reference:

ZEB1, ZEB2

Validated targets of miRNA from TarBase:

unknown : More...

Description:

The miR-200 family is composed of five members arranged as two clusters, miR-200a/200b/429 and miR-200c/141.Ectopic expression of the miR-200 family in 4TO7 carcinoma cells caused a rapid and significant decrease in ZEB1 and ZEB2 levels.Over-expressing the miR-200 family in 4TO7 cells induced a dramatic morphological change from a spindle-like, mesenchymal phenotype towards a more pronounced epithelial phenotype with formation of adheren junctions. Furthermore, overexpression of miR-200 significantly inhibits growth factor-induced directional migration, a hallmark of metastatic cancer cells.This suggests that ectopic expression of the miR-200 family can promote the mesenchymal-epithelial transition and reduce tumor cell migration.

Reference:

The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. | PMID:18411277
Korpal M, Lee ES, Hu G, Kang Y.
J Biol Chem. 2008 May 30;283(22):14910-4. Epub 2008 Apr 14.