hsa-miR-204

acute myeloid leukemia (AML)

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

down-regulated

Validated targets of miRNA from the reference:

HOXA10, MEIS1

Validated targets of miRNA from TarBase:

unknown : More...

Description:

The authors confirmed that miR-204 targets HOXA10 and MEIS1, suggesting that the HOX upregulation observed inNPMc AMLmaybe due in part by loss ofHOX regulators-miRNAs.

Reference:

Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin. | PMID:18308931
Garzon R, Garofalo M, Martelli MP, Briesewitz R, Wang L, Fernandez-Cymering C, Volinia S, Liu CG, Schnittger S, Haferlach T, Liso A, Diverio D, Mancini M, Meloni G, Foa R, Martelli MF, Mecucci C, Croce CM, Falini B.
Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3945-50. Epub 2008 Feb 28.