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Monday, Apr.29, 2024
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| miRNA: |
hsa-miR-7 |
| Disease: |
glioblastoma |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
EGFR |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: miR-7 potently suppressed epidermal growth factor receptor expression, and furthermore it independently inhibited the Akt pathwayvia targeting upstream regulators. miR-7 expression was down-regulated in glioblastoma versus surrounding brain, with a mechanism involving impaired processing. Importantly, transfection with miR-7 decreased viabilityand invasiveness of primary glioblastoma lines.This studyestablishes miR-7 as a regulator of major cancer pathways and suggests that it has therapeutic potential for glioblastoma. |
Reference:
microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma. | PMID:18483236
Kefas B, Godlewski J, Comeau L, Li Y, Abounader R, Hawkinson M, Lee J, Fine H, Chiocca EA, Lawler S, Purow B.
Cancer Res. 2008 May 15;68(10):3566-72. |
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