| miRNA: |
hsa-miR-9 |
| Disease: |
metabolic disease |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
ONECUT-2 |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: miR-9 affects insulin release by decreasing the expression of one cut domain family member 2 (transcription factor ONECUT-2) and causing a rise in levels of synaptotagmin-like protein 4
(SYTL4; also known as granuphilin), a major controller of β-cell secretion. |
Reference:
MicroRNA-9 controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells. | PMID:16831872
Plaisance V, Abderrahmani A, Perret-Menoud V, Jacquemin P, Lemaigre F, Regazzi R.
J Biol Chem. 2006 Sep 15;281(37):26932-42. Epub 2006 Jul 10. |
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