|
|
|
|
Thursday, May.2, 2024
|
|
|
|
|
|
| miRNA: |
hsa-miR-9-1 |
| Disease: |
breast cancer |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Aberrant hypermethylation leads to miRNA gene inactivation in human breast cancer. mir-9-1 gene is already hypermethylated in pre-invasive intraductal lesions, a good correlation between quantitative methylation level and reduction of expression could be demonstrated in a subset of primary human breast cancer specimen (r = 0.8). |
Reference:
Epigenetic inactivation of microRNA gene hsa-mir-9-1 in human breast cancer. | PMID:17948228
Lehmann U, Hasemeier B, Christgen M, Muller M, Romermann D, Langer F, Kreipe H.
J Pathol. 2008 Jan;214(1):17-24. |
|
|
|
|
|
|
