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Friday, May.3, 2024
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miRNA: |
hsa-miR-9-1 |
Disease: |
breast cancer |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
unknown : More... |
Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Aberrant hypermethylation was shown for miR-9-1, miR-124a-3, miR-148, miR-152, and miR-663 in 34-86% of cases in a series of 71 primary human breast cancer specimens. miRNA gene hypermethylation correlated strongly with methylation of known tumour suppressor genes (p = 0.003). After treatment of various breast cancer cell lines with the demethylating agent 5-aza-2'deoxycytidine, reduction of mir-9-1 gene methylation and concomitant reactivation of expression could be observed. For the mir-9-1 gene, which is already hypermethylated in preinvasive intraductal lesions, a good correlation between quantitative methylation level and reduction of expression could be demonstrated in a subset of primary human breast cancer specimen (r = 0.8). |
Reference:
Epigenetic inactivation of microRNA genes in mammary carcinoma. | PMID:18314617
Lehmann U, Hasemeier B, Romermann D, Muller M, Langer F, Kreipe H.
Verh Dtsch Ges Pathol. 2007;91:214-20. |
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