| miRNA: |
hsa-miR-206 |
| Disease: |
breast cancer |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
ER-alpha |
Validated targets of miRNA from TarBase: |
Fstl1,GJA1,Utrn : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Transfection of MCF-7 cells with pre-miR-206 or 2'-O-methyl antagomiR-206 specifically decreased or increased, respectively, ERα mRNA levels.MiR-206 expression was strongly inhibited by ERα agonists, but not by an ERα agonist or progesterone, indicating a mutually inhibitory feedback loop. |
Reference:
The micro-ribonucleic acid (miRNA) miR-206 targets the human estrogen receptor-alpha (ERalpha) and represses ERalpha messenger RNA and protein expression in breast cancer cell lines. | PMID:17312270
Adams BD, Furneaux H, White BA.
Mol Endocrinol. 2007 May;21(5):1132-47. Epub 2007 Feb 20. |
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