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Wednesday, May.15, 2024
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| miRNA: |
hsa-miR-93 |
| Disease: |
vesicular stomatitis |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
L protein,P protein |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: miR-24 and miR-93 could target viral large protein (L protein) and phosphoprotein (P protein) genes, and in variant Dicer1 cells, a lack of host miR-24 and miR-93 was responsible for increased VSV replication. |
Reference:
Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression. | PMID:17613256
Otsuka M, Jing Q, Georgel P, New L, Chen J, Mols J, Kang YJ, Jiang Z, Du X, Cook R, Das SC, Pattnaik AK, Beutler B, Han J.
Immunity. 2007 Jul;27(1):123-34. Epub 2007 Jul 5. |
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