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Wednesday, Apr.24, 2024
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miRNA: |
hsa-miR-15a |
Disease: |
acute promyelocytic leukemia (APL) |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
BCL2, RAS |
Validated targets of miRNA from TarBase: |
unknown : More... |
Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: There is a negative correlation between miR-15a and miR-16-1 expression and BCL2 during ATRA-induced granulocytic differentiation of NB4 cells. |
Reference:
MicroRNA gene expression during retinoic acid-induced differentiation of human acute promyelocytic leukemia. | PMID:17260024
Garzon R, Pichiorri F, Palumbo T, Visentini M, Aqeilan R, Cimmino A, Wang H, Sun H, Volinia S, Alder H, Calin GA, Liu CG, Andreeff M, Croce CM.
Oncogene. 2007 Jun 14;26(28):4148-57. Epub 2007 Jan 29. |
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