Thursday, Mar.28, 2024
miRNA:

hsa-miR-15a

Disease:

chronic lymphocytic leukemia (CLL)

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

Expression pattern of miRNA:

down-regulated

Validated targets of miRNA from the reference:

BCL2

Validated targets of miRNA from TarBase:

unknown : More...

Predicted targets: MIRANDA, TARGETSCAN, PICTAR-VERT

 

Description:

Both miR-15a and miR-16-1 recognize target sites on the 3'UTR of BCL2, an anti-apoptotic oncogene. These miRNAs control the level of BCL2 in normal cells but the expression of the oncogene is increased when the miRNAs are deleted leading to CLL.

 

 

Reference:

miR-15 and miR-16 induce apoptosis by targeting BCL2. | PMID:16166262
Cimmino A, Calin GA, Fabbri M, Iorio MV, Ferracin M, Shimizu M, Wojcik SE, Aqeilan RI, Zupo S, Dono M, Rassenti L, Alder H, Volinia S, Liu CG, Kipps TJ, Negrini M, Croce CM.
Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13944-9. Epub 2005 Sep 15.

 

 
 
 
  miRBase
  Tarbase
  miRGen
  miRGator
  CCBB
  MicroRNA.org
  miRRim
  miRNAMap 2.0
 
 
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