hsa-miR-15a

chronic lymphocytic leukemia (CLL)

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

down-regulated

Validated targets of miRNA from the reference:

BCL2

Validated targets of miRNA from TarBase:

unknown : More...

Description:

miR-15a and miR-16-1, both microRNAs negatively regulate BCL2 at a post-transcriptional level and BCL2 repression induces apoptosis in MEG-01 chronic leukemia cell line and reduced in-vivo tumorigenicity.

Reference:

The role of microRNA and other non-coding RNA in the pathogenesis of chronic lymphocytic leukemia. | PMID:17707831
Calin GA, Pekarsky Y, Croce CM.
Best Pract Res Clin Haematol. 2007 Sep;20(3):425-37.