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Friday, Apr.19, 2024
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| miRNA: |
hsa-miR-15a |
| Disease: |
chronic lymphocytic leukemia (CLL) |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Among the components of the miR-15a/16-1 signature,The authors observed a statistically significant enrichment in AU-rich elements (AREs). By examining the Gene Ontology (GO) database, a significant enrichment in cancer genes (such as MCL1, BCL2, ETS1, or JUN) that directly or indirectly affect apoptosis and cell cycle was found.
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Reference:
MiR-15a and miR-16-1 cluster functions in human leukemia. | PMID:18362358
Calin GA, Cimmino A, Fabbri M, Ferracin M, Wojcik SE, Shimizu M, Taccioli C, Zanesi N, Garzon R, Aqeilan RI, Alder H, Volinia S, Rassenti L, Liu X, Liu CG, Kipps TJ, Negrini M, Croce CM.
Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5166-71. Epub 2008 Mar 24. |
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