| miRNA: |
hsa-miR-10b |
| Disease: |
breast cancer |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
HOXD10 |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: miR-10b is highly expressed in metastatic breast cancer cells and positively regulates cell migration and invasion. The miR-10b induced by Twist proceeds to inhibit translation of the messenger RNA encoding homeobox D10, resulting in increased expression of a well-characterized pro-metastatic gene, RHOC. |
Reference:
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. | PMID:17898713
Ma L, Teruya-Feldstein J, Weinberg RA.
Nature. 2007 Oct 11;449(7163):682-8. Epub 2007 Sep 26. |
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