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Sunday, May.5, 2024
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| miRNA: |
hsa-miR-122a |
| Disease: |
hepatocellular carcinoma (HCC) |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
microarray |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Distinct up-regulations of miR-222, miR-221, and miR-31, and down-regulations of miR-223, miR-126, and miR-122a were identified. Further investigations suggested the highly deregulated miR-223 and miR-222 could unequivocally distinguish HCC from adjacent nontumoral liver, irrespective of viral associations (P<=.0002). |
Reference:
MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1. | PMID:18555017
Wong QW, Lung RW, Law PT, Lai PB, Chan KY, To KF, Wong N.
Gastroenterology. 2008 Jul;135(1):257-69. Epub 2008 Apr 11. |
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