hsa-miR-124a

breast cancer

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

down-regulated

Validated targets of miRNA from the reference:

CDK6

Validated targets of miRNA from TarBase:

unknown : More...

Description:

miR-124a undergoes transcriptional inactivation by CpG island hypermethylation. miR-124a epigenetic silencing mediates cyclin D kinase 6(CDK6)activation and retinoblastoma (Rb) phosphorylation.

Reference:

Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. | PMID:17308079
Lujambio A, Ropero S, Ballestar E, Fraga MF, Cerrato C, Setien F, Casado S, Suarez-Gauthier A, Sanchez-Cespedes M, Git A, Spiteri I, Das PP, Caldas C, Miska E, Esteller M.
Cancer Res. 2007 Feb 15;67(4):1424-9.