miRNA: |
hsa-miR-124a |
Disease: |
cancer |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
CDK6 |
Validated targets of miRNA from TarBase: |
unknown : More... |
Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Be methylated in tumor cells.The epigenetic silencing of miR-124a leads to the activation of cyclin D kinase 6 (CDK6), a bona fide oncogenic factor, and the phosphorylation of the retinoblastoma (Rb) tumor suppressor gene. |
Reference:
CpG island hypermethylation of tumor suppressor microRNAs in human cancer. | PMID:17581274
Lujambio A, Esteller M.
Cell Cycle. 2007 Jun 15;6(12):1455-9. Epub 2007 May 4. |
|
|