|
|
|
|
Tuesday, May.21, 2024
|
|
|
|
|
|
| miRNA: |
hsa-miR-124a |
| Disease: |
medulloblastoma |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
CDK6 |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: We identified putative miR sites in the CDK6 including microRNA 124a, a brain enriched microRNA. Expression of miR 124a was significantly decreased in medulloblastoma cells compared to normal adult cerebellum. Functional association between miR 124a and CDK6 in medulloblastoma was established using luciferase assays. Additionally, re-expression of miR 124a in medulloblastoma cells decreased expression of CDK6 protein. Transfection of miR 124 significantly decreases medulloblastoma cell growth but does not alter apoptosis. Furthermore, in patient samples expression of miR 124a is significantly decreased. Our data strongly indicate that CDK6 is regulated by microRNA 124 in medulloblastoma and that miR 124 modulates medulloblastoma cell growth.
|
Reference:
Regulation of cyclin dependent kinase 6 by microRNA 124 in medulloblastoma. | PMID:18607543
Pierson J, Hostager B, Fan R, Vibhakar R.
J Neurooncol. 2008 Jul 8. [Epub ahead of print] |
|
|
|
|
|
|
