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Saturday, Apr.27, 2024
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| miRNA: |
hsa-miR-433 |
| Disease: |
Parkinson's disease |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
normal |
Validated targets of miRNA from the reference: |
FGF20 |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: The risk allele for rs12720208 disrupts a binding site for microRNA-433, increasing translation of FGF20 in vitro and in vivo. In a cell-based system and in Parkinson disease (PD) brains, this increase in translation of FGF20 is correlated with increased a-synuclein expression, which has previously been shown to cause PD through both overexpression and point mutations. |
Reference:
Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein. | PMID:18252210
Wang G, van der Walt JM, Mayhew G, Li YJ, Zuchner S, Scott WK, Martin ER, Vance JM.
Am J Hum Genet. 2008 Feb;82(2):283-9. Epub 2008 Jan 31. |
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